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MCT oil: a small weight effect with a triglyceride cost

Across 11 randomized trials, people who replaced at least 5 g a day of ordinary long-chain fat with MCT for 4 weeks or more ended up 1.5 lb (0.69 kg) lighter (95% CI 0.28 to 1.1) with 2 lb (0.89 kg) less body fat. The reviewers rated that evidence low to moderate. A 2024 meta-analysis in people with overweight or obesity put the gap at 1.53 percent of body weight (95% CI 0.63 to 2.44) in favor of MCT diets. In one 16 week weight-loss program, the 31 of 49 overweight adults who finished ended 3.7 lb (1.67 kg) lighter on 18 to 24 g of MCT oil a day than on olive oil, with the P value unadjusted. The cost shows in blood fats. A meta-analysis of 7 randomized trials found MCT oil left total, LDL and HDL cholesterol unchanged on average and raised triglycerides by 12 mg/dL (95% CI 0.89 to 24; metric: 0.14 mmol/L, 0.01 to 0.27). That average splits by what the oil replaced. In a subgroup analysis of those few trials, MCT oil raised total and LDL cholesterol against mostly unsaturated oils and showed some evidence of lowering them against longer-chain saturated fats.

Every statement here is tied to a source. The badge says what kind of evidence stands behind it: A is a meta-analysis or systematic review, E is the position of an expert body without its own analysis. How we verify →

We have no USDA entry for mct oil itself in this cohort. The evidence below stands on published studies rather than on a composition table, and we would rather say that than show you a number for something else.

How much is actually in it

What a real portion looks like

What your body absorbs

What it does to your health

Safety, limits and interactions

What people believe that the data does not support

Who this works differently for

What is still unknown

The bottom line

Part of the weight effect may run through appetite. A meta-analysis of laboratory studies found people ate moderately less at the next meal after MCT than after long-chain fat (SMD -0.444, 95% CI -0.808 to -0.080), while their own ratings of hunger barely moved. Coconut oil is sold as an MCT source. In a crossover test with 205 calories of oil in a breakfast smoothie, MCT oil cut lunch intake more than coconut oil, and the authors conclude coconut oil cannot be promoted as having the same effect. In 17 obese women kept on a weight-stable diet for 27 days each, MCT oil raised energy expenditure from 0.90 to 0.95 calories a minute against beef tallow, and the change in body fat volume did not differ. Two questions stay open. Taking caprylic acid MCT with carbohydrate produced fewer ketones than MCT alone in a meta-analysis of 7 trials, of which only 4 were randomized, and 11 g did not differ significantly from 19 g. In older adults without dementia, 4 of 6 randomized trials found better memory scores on MCT, mainly working memory. Those trials used different doses, tests and durations, so there were too few alike to pool and the size of any effect is unknown. Who should be careful. The rise in triglycerides is the finding most people would meet. In an open pilot without a control group, adults with drug-resistant epilepsy taking MCT oil twice a day for 3 months had an estimated 42 percent fewer seizures and reported nausea, stomach ache and loose stools. For preterm babies fed formula, a Cochrane review of 6 small studies in 118 infants found high-MCT formula made little to no difference to weight gain (MD -0.21 g/kg/day, 95% CI -1.24 to 0.83), on low certainty evidence. Those were formulas in infant feeding studies, not MCT oil added to a baby's food. In 64 very low birth weight infants, fat absorption sat at 76 to 84 percent whatever the MCT share, and ketones rose at the highest share. In 6 patients with severe pancreatic insufficiency, MCT was absorbed better than butter fat, and the advantage disappeared once they took pancreatic enzymes. No card here sets an upper daily amount. The weight trials used 18 to 24 g a day, and the epilepsy pilot reported nausea and loose stools. We found no card on pregnancy or on medicines for MCT oil.

Questions about mct oil, answered from the trials

Sources

  1. mctx-daily-r5-07 · randomized crossover trial
    The MCT diet contained 67% of treatment fat as MCT oil (49% octanoate, 50% decanoate) whereas the LCT diet contained exclusively beef tallow as treatment fat. ... Average EE and fat oxidation were greater (P<0.05) during MCT than LCT consumption (0.95+/-0.019 vs 0.90+/-0.024 kcal/min, respectively, for EE and 0.080+/-0.0026 vs 0.075+/-0.0022 g/min, respectively for fat oxidation).
    Int J Obes Relat Metab Disord, 2003 · checked 2026-10-03
  2. mctx-daily-r5-06 · randomized controlled trial
    Forty-nine overweight men and women, aged 19-50 y, consumed either 18-24 g/d of MCT oil or olive oil as part of a weight-loss program for 16 wk. ... MCT oil consumption resulted in lower endpoint body weight than did olive oil (-1.67 +/- 0.67 kg, unadjusted P = 0.013).
    Am J Clin Nutr, 2008 · checked 2026-10-03
  3. mctx-daily-r5-08 · randomized crossover trial
    Medium chain triglycerides are easily hydrolyzed in the intestines and the fatty acids are transported directly to the liver via the portal venous system, in contrast to long-chain fatty acids (LCFAs), which are incorporated into chylomicrons for transport through the lymphatic system or peripheral circulation. ... Mean triglyceride values after canola oil increased 47 percent above baseline (p <0.001), while mean triglyceride values after MCT oil decreased 15 percent from baseline (p <0.001), which is consistent with several other studies involving short- and longer-term feeding with MCT oil.
    Altern Med Rev, 1999 · checked 2026-10-03
  4. mctx-daily-r5-09 · crossover trial
    MCTs are absorbed better than LCTs in the presence of pancreatic insufficiency but require pancreatic extracts for optimal absorption. No advantage is to be expected from replacing usual dietary fats with MCTs if pancreatic supplements are used.
    Scand J Gastroenterol, 1996 · checked 2026-10-03
  5. mctx-daily-r5-10 · randomized controlled trial
    Groups did not differ in growth, formula intake, fat absorption (76-84%), serum glucose, or plasma carnitine levels. Gastrointestinal tolerance was excellent and did not differ among groups. Plasma 3HB was significantly different (p < 0.05) only between the 0 and 50% MCT groups, 50 +/- 10 versus 120 +/- 20 microM, respectively.
    J Pediatr Gastroenterol Nutr, 1993 · checked 2026-10-03
  6. mctx-daily-r5-16 · meta-analysis
    Ketone production was lower when C8 was combined with carbohydrates compared to MCT intake alone. The lower C8 dose group (11 g) did not show a significantly lower ketogenic effect than the higher dose group (19 g).
    Nutrients, 2024 · checked 2026-10-03
  7. ev-mctchol-01 · meta-analysis of randomized controlled trials
    MCT oil intake did not affect total cholesterol (0.04 mmol/L; 95% CI, -0.11 to 0.20; I2 = 33.6%), LDL cholesterol (0.02 mmol/L; 95% CI, -0.13 to 0.17; I2 = 28.7%), or HDL cholesterol (-0.01 mmol/L; 95% CI, -0.10 to 0.09; I2 = 74.1%) levels, but did increase triglycerides (0.14 mmol/L; 95% CI, 0.01-0.27; I2 = 42.8%).
    J Nutr, 2021 · checked 2026-10-07
  8. ev-mctchol-04 · meta-analysis of crossover and parallel trials
    Diets enriched with MCFAs led to significantly higher high-density lipoprotein (HDL) cholesterol concentrations than diets enriched with LCSFAs (0.11 mmol/L; 95% CI: 0.07, 0.15 mmol/L) with no effect on triglyceride, low-density lipoprotein (LDL) cholesterol, and total cholesterol concentrations.
    Am J Clin Nutr, 2018 · checked 2026-10-07
  9. ev-mctchol-07 · randomized controlled trial
    After controlling for body weight, there was a significant effect of time on fasting serum glucose (P = 0.0177) and total cholesterol (P = 0.0386) concentrations, and on diastolic blood pressure (P = 0.0413), with reductions in these variables occurring over time; there was no time-by-diet interaction for any of the parameters studied.
    J Am Coll Nutr, 2008 · checked 2026-10-07
  10. mctx-daily-r5-01 · meta-analysis
    Our findings revealed diets enriched with MCTs are more effective in achieving weight reduction (WMD: -1.53%; 95% CI: -2.44, -0.63; p < 0.01), particularly those containing pure MCTs (WMD: -1.62%; 95% CI: -2.78, -0.46; p < 0.01), compared to long-chain fatty acids (LCTs) enriched diets.
    Clin Nutr, 2024 · checked 2026-10-03
  11. mctx-daily-r5-02 · meta-analysis of RCTs
    In the overall analysis, including all studies, individuals who replaced dietary LCT with MCT showed significantly reduced body weight (WMD, -0.69 kg; 95% confidence interval [CI], -1.1 to -0.28; p = 0.001); body fat (-0.89 kg; 95% CI, -1.27 to -0.51; p < 0.001), and WC (-1.78 cm; 95% CI, -2.4 to -1.1; p < 0.001). The overall quality of the evidence was low to moderate.
    J Am Coll Nutr, 2015 · checked 2026-10-03
  12. mctx-daily-r5-03 · meta-analysis
    Synthesis of combined data showed evidence of a statistically significant moderate decrease in ad libitum energy intake after both acute and chronic ingestion of MCT compared to LCT when assessed under laboratory conditions (mean effect size: -0.444, 95% CI -0.808, -0.080, p < 0.017), despite little evidence of any effect of MCT on subjective appetite ratings or circulating hormones.
    Crit Rev Food Sci Nutr, 2021 · checked 2026-10-03
  13. ev-mctchol-03 · meta-analysis of randomized controlled trials
    CONCLUSIONS: MCT oil does not affect total cholesterol, LDL cholesterol, or HDL cholesterol levels, but does cause a small increase in triglycerides.
    J Nutr, 2021 · checked 2026-10-07
  14. ev-mctchol-09 · systematic review of prospective studies
    The most common AEs included gastrointestinal disturbances (40.6%), hyperlipidemia (12.8%), hyperuricemia (4.4%), lethargy (4.1%), infectious diseases (3.8%) and hypoproteinemia (3.8%).
    World J Pediatr, 2017 · checked 2026-10-07
  15. mctx-daily-r5-04 · meta-analysis of RCTs
    MCT oil intake did not affect total cholesterol (0.04 mmol/L; 95% CI, -0.11 to 0.20; I2 = 33.6%), LDL cholesterol (0.02 mmol/L; 95% CI, -0.13 to 0.17; I2 = 28.7%), or HDL cholesterol (-0.01 mmol/L; 95% CI, -0.10 to 0.09; I2 = 74.1%) levels, but did increase triglycerides (0.14 mmol/L; 95% CI, 0.01-0.27; I2 = 42.8%).
    J Nutr, 2021 · checked 2026-10-03
  16. mctx-daily-r5-11 · meta-analysis of RCTs
    As compared to low MCT formula, preterm infants fed high MCT formula showed little to no difference in weight gain velocity (g/kg/d) during the intervention, with a typical mean difference (MD) of -0.21 g/kg/d (95% confidence interval (CI) -1.24 to 0.83; 6 studies, 118 infants; low-certainty evidence).
    Cochrane Database Syst Rev, 2021 · checked 2026-10-03
  17. mctx-daily-r5-15 · open-label pilot
    Our data although limited by small sample size, shows that there is an estimated 42% reduction (p < 0.0001) in the rate of seizures. The MCT oil supplementation was well tolerated by most subjects except for minor GI side effects like nausea and loose stools.
    Nutr Neurosci, 2023 · checked 2026-10-03
  18. ev-mctchol-10 · position statement
    Replacement of saturated with unsaturated fats lowers low-density lipoprotein cholesterol, a cause of atherosclerosis, linking biological evidence with incidence of CVD in populations and in clinical trials.
    Circulation, 2017 · checked 2026-10-07
  19. mctx-daily-r5-05 · meta-analysis of RCTs
    Subgroup analyses showed that the effects of MCT oil on total cholesterol and LDL cholesterol differed based on the fatty acid profile of the control oil (Pinteraction = 0.003 and 0.008, respectively), with MCT oil increasing total cholesterol and LDL cholesterol when compared to a comparator consisting predominantly of unsaturated fatty acids, and with some evidence for reductions when compared to longer-chain SFAs.
    J Nutr, 2021 · checked 2026-10-03
  20. mctx-daily-r5-14 · randomized crossover trial
    The results of this study confirm the differences that exist between MCT and coconut oil such that coconut oil cannot be promoted as having similar effects to MCT oil on food intake and satiety.
    Physiol Behav, 2017 · checked 2026-10-03
  21. ev-mctchol-02 · meta-analysis of randomized controlled trials
    Subgroup analyses showed that the effects of MCT oil on total cholesterol and LDL cholesterol differed based on the fatty acid profile of the control oil (Pinteraction = 0.003 and 0.008, respectively), with MCT oil increasing total cholesterol and LDL cholesterol when compared to a comparator consisting predominantly of unsaturated fatty acids, and with some evidence for reductions when compared to longer-chain SFAs.
    J Nutr, 2021 · checked 2026-10-07
  22. ev-mctchol-05 · randomized controlled trial
    Rather than having a neutral effect, MCT oil produced total cholesterol concentrations that were not significantly different from those produced by palm oil (MCT oil: 5.87 +/- 0.75 mmol/L; palm oil: 5.79 +/- 0.72 mmol/L) but significantly higher than that produced by high oleic acid sunflower oil (5.22 +/- 0.52 mmol/L).
    Am J Clin Nutr, 1997 · checked 2026-10-07
  23. ev-mctchol-06 · randomized controlled trial
    Compared with corn oil, MCT supplements had no significant effect on plasma lipoprotein profile or TRL apo B-48 and VLDL apo B-100 kinetics.
    Am J Clin Nutr, 2014 · checked 2026-10-07
  24. ev-mctchol-08 · randomized controlled trial
    The MCT group showed an across-time reduction in body weight and WC, an increase in serum C-peptide concentration, a reduction in homeostasis model assessment of insulin resistance, and a decrease in serum cholesterol concentration (P < .05, repeated measures).
    Metabolism, 2007 · checked 2026-10-07
  25. mctx-daily-r5-12 · systematic review of RCTs
    MCT supplementation compared to controls was associated with improved indices of memory function in 4 out of 6 studies, particularly working memory.
    BMC Geriatr, 2022 · checked 2026-10-03
  26. ev-mctchol-11 · meta-analysis of randomized controlled trials
    Seven articles were included in the meta-analysis; LDL cholesterol and HDL cholesterol were reported in 6 studies.
    J Nutr, 2021 · checked 2026-10-07
  27. mctx-daily-r5-13 · systematic review of RCTs
    A meta-analysis was not employed due to the low number of studies, therefore, a true effect measure of MCT supplementation was not explored. ... Further studies are warranted to confirm these findings in terms of optimal dose and MCTs composition, which may protect from memory decline during aging.
    BMC Geriatr, 2022 · checked 2026-10-03

Review. Reviewed on 2026-10-03 for evidence level, dose and population context, and claims a reader could misread. Bioma Learn has no human medical reviewer at this time, and we say so rather than invent one. Methodology. This is information, not medical advice.