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Cod vs salmon: the fat carries the vitamin D, the iodine goes the other way

A meta-analysis of randomized trials in 640 people, with data up to 2014, found that eating fatty fish such as salmon raised blood vitamin D by 6.8 nmol/L (95% CI 3.7 to 9.9). Lean fish such as cod gave 1.9 nmol/L, a result that did not reach significance (95% CI -2.3 to 6.0). The composition tables show why the two fish behave so differently. UK tables, which give averages without a range, list raw farmed salmon at 15.0 g of fat per 3.5 oz (100 g) against 0.6 g in cod. Salmon has 3.25 g of omega-3 fat against 0.08 g, and 4.7 mcg of vitamin D where cod has only a trace. Cod wins on iodine, 196 mcg against 12 mcg per 3.5 oz (100 g), though across eight USDA cod samples the iodine ranged about fifteenfold, from 23 to 361 mcg. A regular fillet of either fish in the US dietary survey weighs 4.9 oz (140 g). In a 4-week trial in 38 healthy young adults eating 26 oz (750 g) a week, salmon lowered fasting triglycerides and raised HDL cholesterol against lean meat while cod did not, and the abstract gives no sizes for either change.

Every statement here is tied to a source. The badge says what kind of evidence stands behind it: A is a meta-analysis or systematic review, E is the position of an expert body without its own analysis. How we verify →

We have no USDA entry for cod | salmon itself in this cohort. The evidence below stands on published studies rather than on a composition table, and we would rather say that than show you a number for something else.

How much is actually in it

What a real portion looks like

What your body absorbs

What cooking and storage change

What it does to your health

Safety, limits and interactions

What people believe that the data does not support

Who this works differently for

What is still unknown

The bottom line

The heart picture beyond that one small trial is thin. Over 6 months in 161 adults, adding 300 g a week of salmon to dietary advice lowered the blood marker CRP by 0.5 mg/L (95% CI -0.9 to -0.2), and cod lowered it by 0.4 mg/L with an interval that reached zero (-0.7 to 0.0). In an 8-week trial in adults with overweight eating 26 oz (750 g) a week, neither fish changed serum cholesterol or triglycerides in the 65 people analyzed. Pooled cohort data from only five studies link the highest lean fish intake with 19% lower stroke risk (RR 0.81, 95% CI 0.67 to 0.99). For fatty fish the 12% estimate crossed no effect (0.74 to 1.04). That is association from too few studies to say whether either fish changes stroke risk at all. How you eat the salmon makes some difference. After a single meal in 13 healthy women, intact salmon raised blood EPA and DHA more than the other versions tested (p < 0.001). Over 2 weeks in an open-label trial in 32 adults, 600 mg of DHA a day from cooked salmon raised plasma DHA by about 80%, the same as algal-oil capsules. In 120 young women through 8 weeks of autumn, vitamin D fell in every group, by 4.3 nmol/L with 100 g a day of a salmon sausage against 15.0 nmol/L in controls. 25 g a day of smoked salmon made no significant difference, and both products supplied about 5 mcg of vitamin D a day. In 21 young women with low iron stores, adding salmon to a bean meal raised iron absorption (p < 0.001), and the abstract does not say by how much. Baking keeps about 90% of vitamin B12 in lean fish and 85% in fatty fish, by USDA factors from a 1975 table set for whole groups of fish. Who should take care. Cod allergy is real in children. In 70 Hong Kong children aged 2 to 10 with confirmed cod allergy, a year of supervised daily cod immunotherapy desensitized 43% against 11% on placebo (risk difference 32%, 95% CI 9% to 51%), with only laboratory evidence of less cross-reaction to salmon. It was treatment under medical supervision and gives no license to feed cod to an allergic child at home. Across 83 studies of fish sold in Belgium, Anisakis larvae turned up in 33% of cod and 5% of Atlantic salmon, and farmed fish were least infected at 2% though still not free of them. The figure counts larvae in fish rather than cases of illness, and a low share is not zero. This page has no card on how raw, cured or cold-smoked fish is made safe from these larvae, so nothing here supports eating either fish raw. FDA samples from 1991 to 2010 averaged 0.111 ppm of mercury in cod and 0.022 ppm in fresh or frozen salmon. FDA and EPA put both fish on their Best Choices list and advise 2 to 3 servings a week from it for people who are or may become pregnant or are breastfeeding. The smoked salmon result above is about vitamin D in 120 young women, and this page has no card on whether chilled smoked fish is safe to eat in pregnancy. The pregnancy trials from Norway are reassuring on mercury and mixed on the rest. In 137 pregnant women, 14 oz (400 g) of cod a week for 16 weeks left hair mercury close to habitual diet, a median 554 against 485 mcg/kg (p = 0.186), and 8% of women in both groups were above the US Environmental Protection Agency reference dose. In a Bergen trial of two 200 g cod meals a week for 16 weeks, urinary iodine ended at a median 98 mcg/L against 73 mcg/L in controls. The infants of the cod group scored lower on a cognitive composite (p = 0.045), a secondary result the authors say needs checking, so this trial does not show that extra cod in pregnancy is free of trade-offs. In 205 preschool children, salmon meals three times a week for 16 weeks did not change IQ scale scores compared with meat meals. Two oil claims failed in the EU register. One said a salmon oil product supports normal blood cholesterol, the other that omega-3 from marine oils such as cod liver oil keeps joints flexible. Both were refused, the register gives no reason, and neither is about eating the fillet.

Each food on its own

Questions answered from the trials

Sources

  1. cdsl-daily-r4-01 · CoFID 2021 dataset
    Cod, flesh only, raw (CoFID 16-372): fat 0.6 g, energy 75 kcal, protein 17.5 g per 100 g; Salmon, farmed, flesh only, raw (CoFID 16-356): fat 15.0 g, energy 217 kcal, protein 20.4 g per 100 g
    CoFID 2021, Public Health England, codes 16-372 and 16-356 · checked 2026-10-03
  2. cdsl-daily-r4-02 · CoFID 2021 dataset
    Cod, flesh only, raw (CoFID 16-372): n-3 poly 0.08 g, iodine 196 ug, vitamin D Tr, vitamin B12 1.5 ug, selenium 23 ug per 100 g; Salmon, farmed, flesh only, raw (CoFID 16-356): n-3 poly 3.25 g, iodine 12 ug, vitamin D 4.7 ug, vitamin B12 4.4 ug, selenium 18 ug per 100 g
    CoFID 2021, Public Health England, codes 16-372 and 16-356 · checked 2026-10-03
  3. cdsl-daily-r4-03 · USDA FoodData Central Foundation Foods, release 2026-04-30
    Fish, cod, Atlantic, wild caught, raw: Total lipid 0.6675 g (0.49-0.95, 8 samples), DHA 0.054 g (0.027-0.085), EPA 0.018 g (0.007-0.03), Iodine 113.7 ug (23.38-360.8, 8 samples); Fish, salmon, Atlantic, farm raised, raw: Total lipid 13.11 g (10.44-16.04, 8 samples), DHA 0.585 g (0.488-0.739), EPA 0.318 g (0.228-0.43)
    USDA FoodData Central, Foundation Foods, release 2026-04-30 · checked 2026-10-03
  4. cdsl-daily-r4-08 · USDA FNDDS
    Fish, cod, baked or broiled (FNDDS 26109120): 1 small/regular fillet 140 g, 1 large fillet 210 g; Fish, salmon, grilled (FNDDS 26137123): 1 small/regular fillet 140 g, 1 large fillet 210 g
    USDA FNDDS, FDC 2706241 and 2706287 · checked 2026-10-03
  5. cdsl-daily-r4-04 · randomized crossover trial
    showed that plasma concentration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) were significantly higher after participants consumed intact salmon compared to the other meals (covariate analysis p < 0.001).
    Food Funct, 2021 · checked 2026-10-03
  6. cdsl-daily-r4-05 · randomized crossover trial
    The addition of fish to the bean meal significantly increased (p < 0.001) iron absorption.
    J Am Coll Nutr, 2008 · checked 2026-10-03
  7. cdsl-daily-r4-06 · randomized controlled trial
    DHA levels increased by approximately 80% in plasma phospholipids and by approximately 25% in erythrocytes in both groups.
    J Am Diet Assoc, 2008 · checked 2026-10-03
  8. cdsl-daily-r4-07 · USDA Table of Nutrient Retention Factors, Release 6 (2007)
    USDA-RETN-R6:2301 FINFISH,<5%FAT,BAKED,WO/DRIPPINGS: vitamin_b12 90%, thiamin 90%, folate 90%, minerals 100%; USDA-RETN-R6:2451 FINFISH,>5%FAT,BAKED,WO/DRIPPINGS: vitamin_b12 85%, thiamin 95%, folate 90%, minerals 100%
    USDA Table of Nutrient Retention Factors, Release 6, 2007, codes 2301 and 2451 · checked 2026-10-03
  9. sf-fpf-r1-4 · agency advice
    Freezing and storing at an ambient temperature of -4°F (-20°C) or below for 7 days (total time), or freezing at an ambient temperature of -31°F (-35°C) or below until solid and storing at an ambient temperature of -31°F (-35°C) or below for 15 hours, or freezing at an ambient temperature of -31°F (-35°C) or below until solid and storing at an ambient temperature of -4°F (-20°C) or below for 24 hours are sufficient to kill parasites. ... The process of heating raw fish sufficiently to kill bacterial pathogens is also sufficient to kill parasites.
    FDA, Fish and Fishery Products Hazards and Controls Guidance, Chapter 5: Parasites · checked 2026-10-08
  10. cdsl-daily-r4-09 · meta-analysis
    the consumption of fatty fish resulted in a mean difference of 6.8 nmol/L (95% CI: 3.7, 9.9 nmol/L; P < 0.0001, I(2) = 0%; 7 study groups), whereas for lean fish the mean difference was 1.9 nmol/L (95% CI: -2.3, 6.0 nmol/L; P < 0.38, I(2) = 37%; 7 study groups).
    Am J Clin Nutr, 2015 · checked 2026-10-03
  11. cdsl-daily-r4-11 · randomized controlled trial
    High intake of fatty fish, but not lean fish, significantly reduced TAG and increased HDL-cholesterol concentrations in fasting serum when compared with lean meat intake. When compared with lean fish intake, fatty fish intake increased serum HDL-cholesterol.
    Br J Nutr, 2016 · checked 2026-10-03
  12. cdsl-daily-r4-12 · randomized controlled trial
    Serum CRP concentrations were lower in the salmon (-0.5 mg/L; 95% CI -0.9, -0.2) and cod (-0.4 mg/L; 95% CI -0.7, 0.0) groups compared with the DA group.
    J Nutr, 2010 · checked 2026-10-03
  13. cdsl-daily-r4-13 · randomized controlled trial
    Serum total neopterin concentration was reduced in the Cod group (median change - 2.65 (25th, 75th percentiles - 3.68, - 0.45) nmol/l, P = 0.018) but not in the Salmon group (median change 0.00 (25th, 75th percentiles - 4.15, 3.05) nmol/l, P = 0.59) when compared with the Control group after 8 weeks.
    Eur J Nutr, 2021 · checked 2026-10-03
  14. cdsl-daily-r4-14 · randomized controlled trial
    A high intake of cod or salmon fillet modulated gut microbiota but did not affect faecal output or serum concentrations of lipids and total bile acids.
    Eur J Nutr, 2021 · checked 2026-10-03
  15. cdsl-daily-r4-23 · randomized controlled trial
    While all groups experienced a decrease in 25(OH)D serum concentrations, the decrease was significantly smaller in the salmon sausage group compared to the control group (-4.3 vs. -15.0 nmol/L, p < 0.05), and no significant difference was observed between the smoked salmon and control group after 8 weeks (p > 0.05).
    Nutrients, 2024 · checked 2026-10-03
  16. cdsl-daily-r4-16 · systematic review
    Cod (Gadus morhua) and Atlantic salmon (Salmo salar), the most consumed fish species in Belgium, have a mean prevalence of 33% and 5% respectively. ... Farmed fish were found to be the least infected (2%) but were still not Anisakidae free.
    Int J Food Microbiol, 2020 · checked 2026-10-03
  17. cdsl-daily-r4-17 · agency monitoring table
    COD | 0.111 | 0.066 | 0.152 | ND | 0.989 | 115 | FDA 1991-2010 ... SALMON (FRESH/FROZEN) | 0.022 | 0.015 | 0.034 | ND | 0.19 | 94 | FDA 1991-2009
    U.S. FDA, Mercury Levels in Commercial Fish and Shellfish (1990-2012) · checked 2026-10-03
  18. cdsl-daily-r4-24 · EU claims register
    POL-HC-7853 Pure salmon oil 500 mg. D alpha tocopherol10 mg.-cps Supports the normal level of blood cholesterol. Non-authorised
    EU Register on nutrition and health claims, claim POL-HC-7853, snapshot 2026-09-21 · checked 2026-10-03
  19. cdsl-daily-r4-25 · EU claims register
    POL-HC-7569 Marine oils such as cod liver oil and fish oil containing eicosapentaenoic acid (EPA : C20:5 n-3) + docosahexaenoic acid (DHA; C22:6 n-3) or long-chain n-3 (omega 3) polyunsaturated fatty acids (LC n-3 PUFA, LC omega 3 PUFA) or ‘Omega 3’ Long-chain Omega 3 polyunsaturated fatty acids help maintain healthy, flexible, mobile and supple joints Non-authorised
    EU Register on nutrition and health claims, claim POL-HC-7569, snapshot 2026-09-21 · checked 2026-10-03
  20. cdsl-daily-r4-10 · randomized controlled trial
    Serum 25-hydroxyvitamin D3 concentration was decreased in all groups after 8 weeks; however, the reduction in the Salmon group was significantly smaller compared with the Cod group (P = 0·013) and the Control group (P = 0·0060).
    Br J Nutr, 2020 · checked 2026-10-03
  21. cdsl-daily-r4-18 · agency advice
    Eat 2 to 3 servings a week from the "Best Choices" list
    U.S. FDA and EPA, Advice about Eating Fish, 2021 · checked 2026-10-03
  22. cdsl-daily-r4-19 · randomized controlled trial
    Post-intervention, the intervention group had median (inter-quartile range) THHg concentrations of 554 (392-805) µg/kg, and the control group 485 (341-740) µg/kg (p = 0.186).
    Environ Int, 2020 · checked 2026-10-03
  23. cdsl-daily-r4-20 · randomized controlled trial
    Postintervention UIC was higher in the intervention group (n = 61) [median (interquartile range, IQR) 98 (64-145) μg/L], compared with control (n = 61) [median (IQR) 73 (52-120) μg/L] (p = 0.028), also after adjusting for baseline UIC (p = 0.048). Infants of mothers in the intervention group had a lower cognitive composite score on the Bayley-III compared with the control group (p = 0.045).
    Thyroid, 2021 · checked 2026-10-03
  24. cdsl-daily-r4-21 · randomized controlled trial
    In general linear models no significant differences between the intervention groups were found in the scale scores of the WPPSI-III tests and the 9-HPT.
    Clin Nutr, 2019 · checked 2026-10-03
  25. cdsl-daily-r4-22 · randomized controlled trial
    At the week 52 end-of-treatment challenges, 15 (43%) OIT participants versus 4 (11%) placebo achieved desensitization (risk difference 32%, 95% CI 9%-51%; p = 0.003) ... immunological evidence of reduced cross-reactivity to salmon and catfish allergens.
    Allergy, 2026 · checked 2026-10-03
  26. sf-lrs-r3-1 · agency advice
    Refrigerated smoked seafood - unless it's in a cooked dish, such as a casserole. Refrigerated smoked seafood, such as salmon, trout, whitefish, cod, tuna, or mackerel, is most often labeled as "nova-style," "lox," "kippered," "smoked," or "jerky." ... Canned or shelf-stable smoked seafood. ... Pregnant women are about 10 times more likely to get listeriosis than other healthy adults.
    US FDA, Listeria (Food Safety for Moms-to-Be) · checked 2026-10-08
  27. cdsl-daily-r4-15 · meta-analysis of cohorts
    Compared with the highest category of intake with lowest category, the summary relative risk was 0.88 [95% confidence interval (CI), 0.74-1.04] for fatty fish intake and 0.81 (95% CI, 0.67-0.99) for lean fish intake.
    Lipids Health Dis, 2018 · checked 2026-10-03

Review. Reviewed on 2026-10-03 for evidence level, dose and population context, and claims a reader could misread. Bioma Learn has no human medical reviewer at this time, and we say so rather than invent one. Methodology. This is information, not medical advice.